Mélatonine et Coumadin

ANTICOAGULANT/ANTIPLATELET DRUGS <<interacts with>> MELATONIN Interaction Rating = Moderate Be cautious with this combination. Severity = High • Occurrence = Possible • Level of Evidence = B

There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Theoretically, melatonin might increase the effect of anticoagulant or antiplatelet drugs. Some drugs with anticoagulant or antiplatelet effects include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, and others.


Tiré de Natural Médecines Comprehensive Database